IMMUNOLOGY2026™ Conference Recordings For Attendees-Generation of early memory CD8+ T cells in humans: markers and mechanisms

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Video Summary

The presentation described a study on human CD8 T cells after AstraZeneca vaccination and subsequent infection. Using HLA class I tetramers, the team analyzed PBMCs from four patients at day 7 and later time points with single-cell RNA/ADT profiling. They identified CD8 T-cell subclusters resembling naïve, early memory, and terminally differentiated states. Importantly, they found that the traditional terminal marker set (CCR7/CD45RA) misses a distinct CD27-positive population. This CD27-positive subset showed stem-like, multipotent features, high FOXP1/TCF1/FOXO1 expression, low cytotoxic effector genes, and long-term persistence in mouse transfer experiments. FOXP1 was shown to be important for maintaining this stem-like state. The study concludes that human vaccine/infection-induced CD8 T cells are more heterogeneous than previously thought, and that CD27 should be considered an additional marker for early-memory/stem-like populations.

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Date April 17, 2026 4:15 PM - 5:45 PM

Room 104C

Session Regulation of Immune Cell Differentiation, Sponsored by the Korean Assoc. of Immunologists (KAI) and the Assoc. of Korean Immunologists in America (AKIA)

Speaker Eui-Cheol Shin

Track Lymphocyte Differentiation and Peripheral Maintenance (LYM)

Year 2026

Keywords

CD8 T cells

AstraZeneca vaccination

HLA class I tetramers

CD27-positive subset

stem-like memory

FOXP1 TCF1 FOXO1

April 17, 2026 4:15 PM - 5:45 PM

104C

Regulation of Immune Cell Differentiation, Sponsored by the Korean Assoc. of Immunologists (KAI) and the Assoc. of Korean Immunologists in America (AKIA)

Eui-Cheol Shin

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

2026